The airline lineup here is genuinely excellent for a route this far off the beaten path. British Airways and Virgin Atlantic both route you through London Heathrow, and both fly newer Club Suite and Upper Class cabins with closing doors, 1-2-1 configuration, and full aisle access from every seat — Virgin's Upper Class adds the social bar and Clubhouse lounge experience at Heathrow, which is worth building a layover around if your schedule allows. KLM connects through Amsterdam in a 1-2-1 lie-flat World Business Class cabin, not door-enclosed but comfortable and reliable, with the added charm of Delft Blue house miniatures served with drinks. Delta routes through Atlanta or Minneapolis in the Delta One Suite, which has become one of the most consistent hard products in the US long-haul fleet — closing door, Tumi amenity kits, and generally strong service reliability. For this itinerary, I lean toward BA or Virgin through London or Delta through Atlanta, since both give you a real hub layover with lounge access rather than a tight connection.